Shaw-Hwa Lo Ph.D., UC Berkeley, 1981 

Professor of Statistics

Research interests

Survival Analysis, Design of Clinical Trials, Resampling Methods, Coverage Problems, Analysis of Incomplete Data, Nonparametric Methods, Asymptotic Theory, Empirical Bayes Methodology. Statistical genetics. Bioinformatics. Genetic network analysis.

Current research projects

• NSF DMS-0710669, Studies of a general framework for high throughout biological learning, Role: PI
• NIH R01 GM07078901, Studies of complex traits for human disorders, Role: PI

Selected recent publications

• Chernoff H, Lo SH, Zheng T (2009) Discovering Influential Variables: A Method of Partitions. Submitted to Annals of Applied Statistics.
• Huang, C.H., Cong, L., Xie, J., Qiao, B., Lo, S.H., and Zheng, T. (2008) Rheumatoid Arthritis-Associated Gene-Gene Interaction Network for Rheumatoid Arthritis Candidate Genes. Genetic Analysis Workshop 16. To appear.
• Qiao, B., Huang, C.H., Cong, L., Xie, J., Lo, S.H., and Zheng, T. (2008) Genome Wide Gene Based Analysis of Rheumatoid Arthritis Associated Interaction with PTPN22 and HLADRB1. Genetic Analysis Workshop 16. To appear.
• Hwang,J-S.,Hu,T-H., Lo, Shaw-Hwa (2008) Evaluation and application of a backward screening algorithm for the identification of a large number of quantitative trait loci. Submitted to Genetics.
• Lo,S.H., Chernoff,H., Cong,L., Ding,Y.,Zheng,T.(2008) Discovering Interactions Among BRCA1 and Other Candidate Genes Involved in Sporadic Breast Cancer. PNAS 105:12387-12392.
• Zheng, T. and Lo, S.H. (2008) Discussion on "Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies" by Nicolae, Meng and Kong." Statistical Science. In press.
• Zheng, T., Wang, S., Cong, L., Ding, Y., Ionita-Laza, I. and Lo, S.H. (2007) Joint study of genetic regulators for expression traits related to breast cancer. In "Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci." BMC Proceedings 1 S1:S10
• Ding, Y., Cong, L., Ionita-Laza, I., Lo, S.H., and Zheng, T. (2007) Constructing gene association network for rheumatoid arthritis using the backward genotype-trait association (BGTA) Algorithm. In "Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci." BMC Proceedings 1 S1:S13.
• Zheng, T. and Lo, SH. (2007) A modified Kendall rank-order association test for evaluating the repeatability of two studies with a large number of objects. In Nair, V. (ed), Advances in Statistical Modeling and Inference: Essays in Honor of Kjell A. Doksum. World Scientific, Hackensack, NJ.
• Zheng T, Wang H, Lo SH (2006) Backward Genotype-Trait Association (BGTA)-Based Dissection of Complex Traits in Case-Control Designs. Human Heredity 62: 196-212.
• Ionita I, Lo SH (2005) Multilocus linkage analysis of affected sib pairs. Human Heredity 60:227-240
• Cespedes C, Said-Salim B, Miller M, Lo SH, Kreiswirth BN, Gordon RJ, Vavagiakis P, Klein RS, Lowy FD (2005) The Clonality of Staphylococcus aureus Nasal Carriage. J Infect Dis. 191(3):444-52
• Lo SH, Zheng T (2004) A demonstration and findings of a statistical approach through reanalysis of inflammatory bowel disease data. Proc Natl Acad Sci U S A 101(28):10386-91
• Shane E, Addesso V, Namerow PB, McMahon DJ, Lo SH, Staron RB, Zucker M, Pardi S, Maybaum S, Mancini D (2004) Prevention of bone loss after cardiac transplantation: an NIH-sponsored randomized controlled clinical trial. New England Journal of Medicine 350:767-76
• Lo SH, Liu X, Shao YZ (2003) A statistical likelihood approach for family-based studies in human genetics. Ann. Hum. Genet. 67: 1-10
• Lo SH, Zheng T (2002) Backward haplotype transmission association (BHTA) algorithm—a fast multiple-marker screening method. Hum. Hered. 53 (4): 197-215.

Genetic statistics research group members

• Shaw-Hwa Lo
• Tian Zheng
• Chien-Hsun Huang (Graduate Student)
• Bo Qiao (Graduate Student)
• Ruixue Fan (Graduate Student)
• Timothy Teravainen (Graduate Student)
• Lei Cong (Programmer)
• Professor Herman Chernoff (Harvard, collaborator)
• Professor Inchi Hu, Maggie Wang (HKSTU, collaborator)
• Professor Hongyu Zhao (Yale, collaborator)
• Dr. Iuliana Ionita (Harvard, collaborator)
• Yuejing Ding (Past member)
• Xin Liu (Past member)
• Hui Wang (Past member)
• Xin Yan (Past member)

Courses

Fall 2006

G6107 - Statistical Inference Theory I
A general introduction to mathematical statistics and statistical decision theory. Elementary decision theory, Bayes inference, Neyman-Pearson theory, hypothesis testing, uniformity, most powerful unbiased tests, confidence sets. Estimation: methods, theory, and asymptotic properties. Likelihood ratio tests, multivariate distribution. Elements of general linear hypothesis, invariance, nonparametric methods, sequential analysis.

G8329 - Statistical Methods in Genetic Epidemiology